Welcome to Spring 2015!
AAPS Student Chapter is pleased to invite you to an exciting opportunity to learn and get basic training in our equipment workshop on:
“Hot Melt Extrusion” by
Simerdeep Singh Gupta, Ph.D.
Post-Doctoral Fellow, St. John’s University
February 11, 2014 (Wednesday) @ 4-5 PM (B2, St. Albert’s Hall)
*Refreshments served afterwards!
Abstract: The prospect for the development of solid dispersion has greatly improved during the past decade due to the introduction of hot melt extrusion (HME) in the pharmaceutical field. HME has many advantages over other solvent-based technologies used for preparation of solid dispersions. It is a continuous, less time-consuming process that can be scaled up relatively easily. It is also less prone to batch-to-batch variability than other processes. Also, being solvent-free, it poses minimal environmental hazards. However, there are still many challenges in the development of new drug products by melt extrusion. Being a relatively new technology in the pharmaceutical field, the formulation and processing parameters of HME are not fully understood. In most of the published reports, it is not defined how the appropriate polymers, drug-polymer blends and the processing temperatures are selected. A good understanding of the material properties, such as the glass transition temperature (Tg) and the melt viscosity of polymers as well as drug-polymer blends and the drug-polymer miscibility is needed before the development of processing conditions for any new products. The drug-polymer mixtures should also be extrudable at as low a temperature as possible to minimize potential of degradation of drug, polymer or both.
About the Speaker: Simerdeep Singh Gupta, Ph.D. is currently a post-doctoral research fellow at St. John’s University, specializing in factors affecting miscibility and extrusion of solid dispersions of various drug-polymer combinations by hot melt extrusion technique. He received his Ph.D.’14 and M.S.’10 in Industrial Pharmacy at St. John’s University (Queens Campus, NY). His doctoral dissertation covered the research area of rheology aspects of Hot Melt Extrusion for solubility enhancement of poorly water soluble drugs. Dr. Gupta investigated formulation and processing factors that affect the performance of solid dispersions. Dr. Gupta has several research achievements in his career including the design and completion a Master’s thesis project on formulation of polymeric nanoparticles using design of experiment approach prepared by nanoprecipitation for brain targeting, and investigation of process and formulation parameters for formulation of cocrystals entrapped in cyclodextrin complex by supercritical fluid processing.
Additionally, Dr. Gupta also played a key role in establishing hot melt extrusion and film casting technology at St. John’s University, NY and was responsible for planning and execution of a grant proposal by Catalent Pharma Solutions in the area of hot melt extrusion. He has been a recipient to various awards like NJPhAST scholarship, FDD travelship award, Catalent R&D recognition award and Modified Release Focus Group-Shering Plough travelship award at AAPS conference. Dr. Gupta has several publications to his account and has made many poster and podia presentations at international conferences. As a graduate student, Dr. Gupta also served as a Chair for AAPS Student Chapter in 2012-13 academic year.